RoutinEDA: expanding the scope and downscaling the format of high throughput Effect-Directed Analysis for routine water cycle monitoring and effective control

stoffen: meerdere stofgroepen
status: lopend


  • biologische effectstudie
  • meerdere stofgroepen
  • afronding in 2021

Vrije Universiteit Amsterdam

Zeven bedrijven en een instituut zijn betrokken bij dit project. Mogelijk worden ook enkele waterschappen betrokken. Projectleider is M. Lamoree (Vrije Universiteit Amsterdam)

Partnershipprogramma TTW-STOWA-KWR-TKI Watertechnologie, projectnummer 15747.

A large variety of organic contaminants end up in the water cycle. This is of concern as they might adversely affect ecosystem and public health. Bioactive compounds can be identified using Effect-Directed Analysis (EDA) approaches. In this project, a previously developed High-Throughput EDA platform acts as the basis to achieve routine EDA. Bioassays will be developed and/or miniaturized that can direct the identification of (metabolites of) antibiotics, pharmaceuticals and compounds causing oxidative stress. The project will address the most relevant toxicological endpoints while demonstrating a high identification success rate. Furthermore, screening protocols for successful identification of active compounds will be developed based on Met-ID principles. RoutinEDA will finally advance EDA to nanoscale in which post separation microfluidic spotters will be combined with microarray toxicity bioassays.